US numbers continue to worsen, vaccine efforts accelerate worldwide, and researchers examine a new virus variant. Here’s what you should know:

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The pandemic is likely to get worse in the US even as vaccinations continue

The US’ daily coronavirus death toll has reached a record high on five of the last 10 days, and it topped 4,000 on Thursday as cases continue to rise almost everywhere. Arizona leads the country in hospitalizations and cases, and Atlanta recently reopened its field hospital to keep up with record numbers of patients. The surge is also particularly bad in Southern California: Coronavirus kills someone every 15 minutes on average in Los Angeles, the county’s public health director announced earlier this week. Ambulance crews have been told to ration oxygen for patients most in need. And some overflow patients have even been moved to hospital hallways and gift shops.

But the country also set a less grim record Thursday: More than 600,000 coronavirus shots were administered in 24 hours, the most in a one-day period since vaccination efforts began. So far, the rollout has been slower than anticipated. While the Trump administration’s policy has been to hold back half of US shots for second doses, Biden’s team has announced that they will release all available doses once he enters office. In an interview on Thursday, Anthony Fauci added that there were always going to be hiccups, and vaccinations are likely to speed up in the weeks to come. But, he added, the pandemic will get worse before it gets better. Until enough people have been vaccinated, everyone must stay vigilant, whether they’ve received a shot or not.

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Vaccine efforts accelerate around the world

On Thursday, Brazilian officials said that a vaccine from Chinese company Sinovac is effective. The company has already sold some 300 million doses, primarily to low- and middle-income countries, as it awaits approval. Meanwhile, in the EU, regulators approved Moderna’s vaccine. Some have speculated they may also make a decision about the Oxford-AstraZeneca vaccine, which has already been approved for use in the UK and India, by the end of the month.

On Sunday, India’s drugs controller general also granted emergency approval to Covaxin, a vaccine developed jointly by Bharat Biotech and the Indian government. The announcement kicks off an ambitious drive to inoculate 300 million people in the country’s first stage of vaccinations. The scientific community quickly criticized the news, because Covaxin has yet to complete its Phase III trials and has not produced sufficient efficacy and safety data. Later in the week, a national network of scientists put out a statement asking the government to reconsider its approval of the vaccine.

A new virus variant spreads as the US ramps up genetic sequencing

Since it was announced last month, a new, reportedly more transmissible variant of SARS-CoV-2, known as B.1.1.7, has spread across the UK and into the US. As of this week, the CDC has identified more than 50 cases of the mutated virus in California, Florida, Colorado, Georgia, and New York. Officials point out that these numbers likely don’t reflect the number of cases actually circulating in the US, and they add that there’s no evidence this variant is more deadly, though it appears to spread more rapidly. A new study from Pfizer found that the company’s coronavirus vaccine appears to protect against this new mutated version.

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